Bidirectional interactions between the immune system and the nervous system are
increasingly appreciated as playing a pathogenic role in chronic pain. Unraveling the …

Millions of people suffer from arthritis worldwide, consistently struggling with daily activities
due to debilitating pain evoked by this disease. Perhaps the most intensively investigated …

Chronic pain associated with joint disorders, such as rheumatoid arthritis (RA), osteoarthritis
(OA) and implant aseptic loosening (AL), is a highly debilitating symptom that impacts …

Abstract Purpose of Review Chronic pain in osteoarthritis (OA) is characterized by pain
sensitization, which involves both peripheral and central mechanisms. Studies suggest …

In this narrative review, we discuss the emerging role of innate immunity in osteoarthritis
(OA) joint pain. First, we give a brief description of the pain pathway in the context of OA …

Chronic pain is a substantial personal and societal burden worldwide. Osteoarthritis (OA) is
one of the leading causes of chronic pain and is increasing in prevalence in accordance …

Chronic neuropathic and inflammatory pain is a major public health problem. Nociceptors
undergo sensitization, first in peripheral tissues then in the central nervous sytem, via …

Osteoarthritis is the most common form of joint disease and is one of the leading causes of
chronic pain. Given the multi-factorial nature, numerous efforts have been made to clarify the …

Pain is the major debilitating symptom of osteoarthritis (OA), which is difficult to treat. In OA
patients joint tissue damage only poorly associates with pain, indicating other mechanisms …

Pain is a main symptom in inflammation, and inflammation induces pain via inflammatory
mediators acting on nociceptive neurons. Macrophages and microglia are distinct cell types …