Previous studies demonstrate that activation of pancreatic ER kinase (PERK) protects
oligodendrocytes against inflammation in the experimental autoimmune encephalomyelitis …

In mammals, the canonical nuclear factor κB (NF-κB) signaling pathway activated in
response to infections is based on degradation of IκB inhibitors. This pathway depends on …

Microglia are brain macrophages and, as such, key immune-competent cells that can
respond to environmental changes. Understanding the mechanisms of microglia-specific …

IκB kinase-1 and IκB kinase-2 (IKK1 and IKK2; also called IKKα and IKKβ, respectively) are
part of the signal complex that regulates NF-κB activity in many cell types, including …

The transcription factor NF-κB is a regulator of cell death or survival. To investigate the role
of NF-κB in neuronal cell death, we studied its activation in a rodent model of stroke. In the …

Here we review evidence of roles for NF-κB in the regulation of developmental and synaptic
plasticity, and cell survival in physiological and pathological settings. Signaling pathways …

Tumour necrosis factor mediates chronic inflammatory pathologies including those affecting
the central nervous system, but non-selective tumour necrosis factor inhibitors exacerbate …

Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous
system (CNS) that afflicts over 2 million people worldwide. On the basis of the temporal …

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NF-κB is a transcription factor that regulates numerous physiological functions, and that is
involved in the pathogenesis of various diseases. In the nervous system there is evidence …