NIK signaling in dendritic cells but not in T cells is required for the development of effector T cells and cell-mediated immune responses
The canonical NF-κB pathway is a driving force for virtually all aspects of inflammation.
Conversely, the role of the noncanonical NF-κB pathway and its central mediator NF-κB …
Conversely, the role of the noncanonical NF-κB pathway and its central mediator NF-κB …
NF-κB regulation by IκB kinase in primary fibroblast-like synoviocytes
NF-κB is a key regulator of inflammatory gene transcription and is activated in the
rheumatoid arthritis (RA) synovium. In resting cells, NF-κB is retained as an inactive …
rheumatoid arthritis (RA) synovium. In resting cells, NF-κB is retained as an inactive …
Silencing IFN-γ binding/signaling in astrocytes versus microglia leads to opposite effects on central nervous system autoimmunity
X Ding, Y Yan, X Li, K Li, B Ciric, J Yang… - The Journal of …, 2015 - journals.aai.org
IFN-γ, the hallmark cytokine of Th1 cells, plays an important role in experimental
autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Thus far, the …
autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. Thus far, the …
Antigen-presenting innate lymphoid cells orchestrate neuroinflammation
Pro-inflammatory T cells in the central nervous system (CNS) are causally associated with
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …
multiple demyelinating and neurodegenerative diseases,,,,–, but the pathways that control …
Crosstalk in NF-κB signaling pathways
NF-κB transcription factors are critical regulators of immunity, stress responses, apoptosis
and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn …
and differentiation. A variety of stimuli coalesce on NF-κB activation, which can in turn …
Innate IFN‐γ promotes development of experimental autoimmune encephalomyelitis: a role for NK cells and M1 macrophages
LS Dungan, NC McGuinness, L Boon… - European journal of …, 2014 - Wiley Online Library
The role of IFN‐γ in the pathogenesis of autoimmune diseases is controversial. Although
Th1 cells can induce experimental autoimmune encephalomyelitis (EAE), IFN‐γ can …
Th1 cells can induce experimental autoimmune encephalomyelitis (EAE), IFN‐γ can …
IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery
H Lian, DJ Shim, SSK Gaddam… - Molecular …, 2012 - Springer
Background The transcription factor NFκB is an important mediator of cell survival and
inflammation in the immune system. In the central nervous system (CNS), NFκB signaling …
inflammation in the immune system. In the central nervous system (CNS), NFκB signaling …
NF-κB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-κB activation
K Hadian, RA Griesbach, S Dornauer… - Journal of Biological …, 2011 - ASBMB
The IκB kinase (IKK) complex acts as a gatekeeper of canonical NF-κB signaling in
response to upstream stimulation. IKK activation requires sensing of ubiquitin chains by the …
response to upstream stimulation. IKK activation requires sensing of ubiquitin chains by the …
Testing NF-κB-based therapy in hemiparkinsonian monkeys
Parkinson's disease (PD) is the most common human neurodegenerative disorder affecting
movement, balance, flexibility, and coordination. Despite intense investigation, no effective …
movement, balance, flexibility, and coordination. Despite intense investigation, no effective …
The kinase IKKα inhibits activation of the transcription factor NF-κB by phosphorylating the regulatory molecule TAX1BP1
N Shembade, R Pujari, NS Harhaj, DW Abbott… - Nature …, 2011 - nature.com
In response to stimulation with proinflammatory cytokines, the deubiquitinase A20 inducibly
interacts with the regulatory molecules TAX1BP1, Itch and RNF11 to form the A20 ubiquitin …
interacts with the regulatory molecules TAX1BP1, Itch and RNF11 to form the A20 ubiquitin …