Photoactive G-quadruplex ligand identifies multiple G-quadruplex-related proteins with extensive sequence tolerance in the cellular environment
G-Quadruplex (G4) is a noncanonical nucleic acid secondary structure with multiple
biofunctions. Identifying G4-related proteins (G4RPs) is important for understanding the …
biofunctions. Identifying G4-related proteins (G4RPs) is important for understanding the …
Ligand design to acquire specificity to intended G‐quadruplex structures
S Asamitsu, T Bando… - Chemistry–A European …, 2019 - Wiley Online Library
AG‐quadruplex is a nucleic acid secondary structure that is adopted by guanine‐rich
sequences, and is considered to be relevant in various pharmacological and biological …
sequences, and is considered to be relevant in various pharmacological and biological …
Nucleic acid detection using G-quadruplex amplification methodologies
BT Roembke, S Nakayama, HO Sintim - Methods, 2013 - Elsevier
In the last decade, there has been an explosion in the use of G-quadruplex labels to detect
various analytes, including DNA/RNA, proteins, metals and other metabolites. In this review …
various analytes, including DNA/RNA, proteins, metals and other metabolites. In this review …
Direct quantification of loop interaction and π–π stacking for G-quadruplex stability at the submolecular level
The well-demonstrated biological functions of DNA G-quadruplex inside cells call for small
molecules that can modulate these activities by interacting with G-quadruplexes. However …
molecules that can modulate these activities by interacting with G-quadruplexes. However …
Structure and function of multimeric G-quadruplexes
S Kolesnikova, EA Curtis - Molecules, 2019 - mdpi.com
G-quadruplexes are noncanonical nucleic acid structures formed from stacked guanine
tetrads. They are frequently used as building blocks and functional elements in fields such …
tetrads. They are frequently used as building blocks and functional elements in fields such …
G‐quadruplex structures and their interaction diversity with ligands
S Zhang, Y Wu, W Zhang - ChemMedChem, 2014 - Wiley Online Library
G‐Quadruplexes are distinct nucleic acid secondary structures that are formed from G‐rich
DNA and RNA sequences; they are built around successive G‐tetrads of Hoogsteen …
DNA and RNA sequences; they are built around successive G‐tetrads of Hoogsteen …
G-quadruplexes: from guanine gels to chemotherapeutics
TM Bryan, P Baumann - Molecular biotechnology, 2011 - Springer
G-quartets are square planar arrangements of four guanine bases, which can form
extraordinarily stable stacks when present in nucleic acid sequences. Such G-quadruplex …
extraordinarily stable stacks when present in nucleic acid sequences. Such G-quadruplex …
Biological relevance and therapeutic potential of G-quadruplex structures in the human noncoding transcriptome
M Tassinari, SN Richter, P Gandellini - Nucleic Acids Research, 2021 - academic.oup.com
Noncoding RNAs are functional transcripts that are not translated into proteins. They
represent the largest portion of the human transcriptome and have been shown to regulate …
represent the largest portion of the human transcriptome and have been shown to regulate …
Seven essential questions on G-quadruplexes
SLB König, AC Evans, JL Huppert - 2010 - degruyter.com
The helical duplex architecture of DNA was discovered by Francis Crick and James Watson
in 1951 and is well known and understood. However, nucleic acids can also adopt …
in 1951 and is well known and understood. However, nucleic acids can also adopt …
Direct visualization of both DNA and RNA quadruplexes in human cells via an uncommon spectroscopic method
A Laguerre, JMY Wong, D Monchaud - Scientific reports, 2016 - nature.com
Guanine-rich DNA or RNA sequences can fold into higher-order, four-stranded structures
termed quadruplexes that are suspected to play pivotal roles in cellular mechanisms …
termed quadruplexes that are suspected to play pivotal roles in cellular mechanisms …