The aim of the present study was to elucidate the role of mitochondria in the development of
heart failure following ischemia/reperfusion. Although mitochondria were increasingly …

Reperfusion injury, the paradoxical tissue response that is manifested by blood flow-
deprived and oxygen-starved organs following the restoration of blood flow and tissue …

Mitochondria play an important role in cell death and cardioprotection. During ischemia,
when ATP is progressively depleted, ion pumps cannot function resulting in a rise in calcium …

The heart is the most metabolically flexible organ with respect to the use of substrates
available in different states of energy metabolism. Cardiac mitochondria sense substrate …

Once considered simply as the main source of ATP, mitochondria are now implicated in the
control of many additional aspects of cell physiology, such as calcium signaling, and …

Acute myocardial infarction is the leading cause of cardiovascular‑related mortality and
chronic heart failure worldwide. As regards treatment, the reperfusion of ischemic tissue …

Mitochondria are increasingly recognized as lynchpins in the evolution of cardiac injury
during ischemia and reperfusion. This review addresses the emerging concept that …

As reperfusion therapies have become more widely used in acute myocardial infarction
patients, ischemia-induced myocardial damage has been markedly reduced, but reperfusion …

The current standard of care for acute myocardial infarction or 'heart attack'is timely
restoration of blood flow to the ischemic region of the heart. While reperfusion is essential for …

Myocardial function is dependent on a constant supply of oxygen from the coronary
circulation. A reduction of oxygen supply due to coronary obstruction results in myocardial …