T-regulatory cells (Tregs) play a fundamental role in the creation and maintenance of
peripheral tolerance. Deficits in the numbers and/or function of Tregs may be an underlying …

Background: The critical role for regulatory T cells (Treg) in suppressing autoimmune
pathology is now well recognised. However, the extent to which defects in regulation can be …

Introduction Accumulating evidence suggests that defective regulation is an essential
underlying cause of autoimmunity. The development of type 1 diabetes in the NOD mouse …

Regulatory T-cells (Tregs) play important role in regulation of immune responses to self-
antigens. Alterations in frequency and function of Tregs have been reported in Type 1 …

Since their discovery decades ago, regulatory T (Treg) cells have prompted many
investigations into their potential role in the generation or prevention of autoimmune …

Since the discovery of specialized T cells with regulatory function, harnessing the power of
these cells to ameliorate autoimmunity has been a major goal. Here we collate the evidence …

The immune system is tasked with defending the host from a wide array of pathogens and
environmental insults. When uncontrolled, this endeavor may lead to off-target reactivity to …

Type 1 diabetes mellitus (T1DM) is a T cell-mediated autoimmune disease characterized by
the destruction of pancreatic β cells. Numerous studies have demonstrated the key role of …

Despite many decades of investigation uncovering the autoimmune mechanisms underlying
Type 1 Diabetes (T1D), translating these findings into effective therapeutics has proven …

OBJECTIVE—Regulatory T-cells (Tregs) have catalyzed the field of immune regulation.
However, translating Treg-based therapies from animal models of autoimmunity to human …