[HTML][HTML] Predictive toxicology today: the transition from biological knowledge to practicable models
R Benigni - Expert Opinion on Drug Metabolism & Toxicology, 2016 - Taylor & Francis
For a long time, animal toxicology has been the major source of information on chemical risk
assessment. The study of the effects of chemicals on apical toxicity end points has provided …
assessment. The study of the effects of chemicals on apical toxicity end points has provided …
FutureTox II: Contemporary Concepts in Toxicology: “Pathways to Prediction: In Vitro and In Silico Models for Predictive Toxicology”
SA Elmore, AM Ryan, CE Wood… - Toxicologic …, 2014 - journals.sagepub.com
The Society of Toxicology (SOT) held a very successful FutureTox II Contemporary Concepts
in Toxicology (CCT) Conference in Chapel Hill, North Carolina, on January 16 and 17, 2014 …
in Toxicology (CCT) Conference in Chapel Hill, North Carolina, on January 16 and 17, 2014 …
[HTML][HTML] Advances in and applications of predictive toxicology: 2022
While the first use of the term “Predictive Toxicology” was mainly focusing on in silico
approaches and applied almost synonymously to computational toxicology (Helma, 2005) it …
approaches and applied almost synonymously to computational toxicology (Helma, 2005) it …
Predictive toxicology: an overview
JF Sina - Annu Rep Med Chem, 1998 - books.google.com
Introduction-Viewed simplistically, there are three major aspects to the field of in vitro
toxicology today: 1) models already available to address specific issues, 2) validating and …
toxicology today: 1) models already available to address specific issues, 2) validating and …
[图书][B] New horizons in predictive toxicology: current status and application
AGE Wilson - 2012 - books.google.com
The sophistication of modelling and simulation technologies have improved dramatically
over the past decade and their applications in toxicity prediction and risk assessment are of …
over the past decade and their applications in toxicity prediction and risk assessment are of …
FutureTox III: bridges for translation
DR Juberg, TB Knudsen, M Sander… - Toxicological …, 2017 - academic.oup.com
Future Tox III, a Society of Toxicology Contemporary Concepts in Toxicology workshop, was
held in November 2015. Building upon Future Tox I and II, Future Tox III was focused on …
held in November 2015. Building upon Future Tox I and II, Future Tox III was focused on …
[HTML][HTML] Predictive toxicity: grand challenges
OR Pelkonen - Frontiers in pharmacology, 2010 - frontiersin.org
Chemicals, be they exogenous or endogenous, affect organisms. Sometimes these effects
are considered beneficial, for example when pharmaceuticals are used to treat diseases or …
are considered beneficial, for example when pharmaceuticals are used to treat diseases or …
Tox21 and adverse outcome pathways
C Roper, RL Tanguay - An introduction to interdisciplinary toxicology, 2020 - Elsevier
Toxicology in the 21st century (Tox21) is a consortium of five government agencies that set
out to advance high-throughput screening while transitioning from mammalian model …
out to advance high-throughput screening while transitioning from mammalian model …
Computational toxicology: Its essential role in reducing drug attrition
RT Naven, S Louise-May - Human & Experimental …, 2015 - journals.sagepub.com
Predictive toxicology plays a critical role in reducing the failure rate of new drugs in
pharmaceutical research and development. Despite recent gains in our understanding of …
pharmaceutical research and development. Despite recent gains in our understanding of …
[图书][B] Mode-of-Action-Guided, Molecular Modeling-Based Toxicity Prediction: A Novel Approach for In Silico Predictive Toxicology
P Gong, S Thangapandian, Y Li, G Idakwo, J Luttrell IV… - 2019 - Springer
Computational toxicology is a sub-discipline of toxicology concerned with the development
and use of computer-based models and methodology to understand and predict chemical …
and use of computer-based models and methodology to understand and predict chemical …