CYP3A4, an isoform of cytochrome P450 enzymes, is responsible for the metabolism of 45%
to 60% of currently prescribed drugs. It has been shown that CYP3A4* 1G, a single …

Background CYP3A4, CYP3A5 and CYP3A7 are hepatic enzymes that metabolize about
50% of drugs on the market, with a large overlap in their specificities. We investigated the …

Objective We investigated whether differences in pharmacokinetics of midazolam, a CYP3A
probe, could be demonstrated between subjects with different CYP3A4 and CYP3A5 …

The molecular basis for the wide interindividual variability of cytochrome P450 (CYP) 3A
metabolic activity was studied in vivo at a genetic level. A single oral dose of midazolam was …

What is known and Objective: Interindividual variability in drug responses may be
attributable to genetically determined alteration in enzyme activity. In this study, we …

Purpose To explore the effect of gene polymorphisms of propofol GABAA receptor and
metabolic enzyme on drug susceptibility during the induction period of general anesthesia …

Methods We enrolled 203 women scheduled for abdominal total hysterectomy or
myomectomy under general anaesthesia. Intravenous fentanyl patient-controlled analgesia …

Background The impact of polymorphic cytochrome P450 CYP2D6 enzyme on oxycodone's
metabolism and clinical efficacy is currently being discussed. However, there are only spare …

Purpose To investigate whether the CYP3A4* 1G genetic polymorphism contributes to the
variability in CYP3A activity and response to fentanyl. Methods One hundred and forty-three …

The field of pharmacogenomics seeks to understand how an individual's unique gene
sequence can affect their response to certain drugs. It is particularly relevant in anesthesia …