Previous studies of propofol (2, 6-diisopropylphenol) pharmacology have shown that this
widely used anaesthetic drug is extensively cleared from the body by conjugation of the …

PURPOSE: This study aimed to investigate the impact of CYP3A4* 1G genetic
polymorphism on metabolism of fentanyl in Chinese patients undergoing lower abdominal …

CYP3A activity in adults varies between individuals and it has been suggested that this has
a genetic basis, possibly related to variant alleles in CYP3A4 and CYP3A5 genes …

Background The etiology of postoperative cognitive dysfunction (POCD) remains unclear but
toxicity of anesthetic drugs and their metabolites could be important. We aimed to assess the …

Objectives Diazepam is widely used to relieve preoperative anxiety in patients. The
objective of this study was to investigate the effects of polymorphism in CYP2C19 and the …

Abstract The current Dutch Pharmacogenetics Working Group (DPWG) guideline, describes
the gene–drug interaction between CYP2D6 and the opioids codeine, tramadol and …

A method for simultaneous phenotyping and genotyping for CYP2D6 and CYP2C19 was
tested. Six healthy volunteers were selected (three extensive and three poor metabolisers …

Background: Oxycodone is a semi‐synthetic opioid with a μ‐receptor agonist‐mediated
effect in several pain conditions, including post‐operative pain. Oxycodone is metabolized to …

Cytochrome P450 enzymes of subfamily 3A account for as much as 30 and 80% of total
P450 content in liver and intestine, respectively [1, 2]. Their abundant expression, as well as …

Genetic polymorphism for cytochrome 450 (P450) enzymes leads to interindividual
variability in the plasma concentrations of many drugs. In some cases, P450 genotype …