The Cytochrome P450 is the major enzyme involved in drug metabolism. CYP enzymes are
responsible for the metabolism of most clinically used drugs. Individual variability in CYP …

Objective To investigate the role of CYP2D6 phenotype in the outcome of postoperative (PO)
pain (POP) treatment. Design Longitudinal cohort study. Open-label trial with post hoc …

Aim Human cytochrome P450 3A4 is the most abundant isoform of P450 enzyme in the liver.
It plays an important role in the metabolism of wide variety of xenobiotic and endogenous …

Aim Differences in the frequency of distribution of the cytochrome P450 (CYP) allelic variants
have been demonstrated between distinct ethnic groups, contributing to observed …

Background Oxidation of propofol to 4-hydroxypropofol represents a significant pathway in
the metabolism of this anesthetic agent in humans. The aim of this study was to identify the …

Background and purpose: The major drug‐metabolizing enzymes for the oxidation of
oxycodone are CYP2D6 and CYP3A. A high interindividual variability in the activity of these …

There is substantial evidence for a causal relationship between genetic variability of the
CYP2D6 gene and changes in the pharmacokinetics of drugs. Therefore, knowledge of …

Polymorphisms in cytochrome P450 genes encoding enzymes of critical importance for drug
metabolism have the highest genetic influence on interindividual variations in drug …

Background: Data on the frequency of pharmacogenetic polymorphisms in the Croatian
population are limited. We determined and analyzed frequencies for the most important …

A comment on this article appears in" Pharmacogenetics of anesthetic and analgesic
agents: CYP2D6 genetic variations." Anesthesiology. 2005 Nov; 103 (5): 1099; author reply …