Objectives Cytochrome P450 (CYP) 3A enzymes are key metabolizing enzymes for many
chemotherapeutic agents, and detection of functionally significant CYP3A genetic variants …

Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome
P450 2D6 (CYP2D6); hence, the efficacy and safety of codeine are governed by CYP2D6 …

Codeine is bioactivated to morphine, a strong opioid agonist, by the hepatic cytochrome
P450 2D6 (CYP2D6); hence, the efficacy and safety of codeine as an analgesic are …

Background Recent studies have reported the clinical importance of CYP2C19 and ABCB1
polymorphisms in an individualized approach to clopidogrel treatment. The aims of this …

Pharmacogenetics deals with clinically significant hereditary variations in the response to
drugs due to altered drug disposition and abnormal drug action in affected persons. In …

Fentanyl is an anesthetic/analgesic commonly used in surgical and recovery settings.
CYP3A4 and CYP3A5 encode enzymes, which metabolize fentanyl; genetic variants in …

Sažetak Cytochrome P450 genetic polymorphisms are responsible for individual variations
in drug metabolism and drug-drug interactions. They are very important for …

Aim To observe the subcellular expression of UDP-glucuronosyltransferase 1A6 (UGT1A6)
and cytochrome P-450 1A1 (CYP1A1) mRNA in the human brain and investigate the effect …

Purpose Phenprocoumon, similar to other coumarin-derived anticoagulants, is associated
with a large variation in the individual dose requirement to achieve stable anticoagulation …

Genetic polymorphisms result in absent enzyme activity of CYP2D6 (poor metabolizers, PM)
in about 10% of the Caucasian population. This study investigates whether the PM genotype …