Mitochondria serve as a “powerhouse” which provides near 90% of ATP necessary for cell
life. However, recent studies provide strong evidence that mitochondria also play a central …

Several drug targets have been amenable to drug discovery pursuit not until the
characterization of the mitochondrial permeability transition pore (MPTP), a pore with an …

The mitochondrial permeability transition pore (MPTP) plays a key role in cell death, yet its
molecular identity remains uncertain. Although knock-out studies have confirmed critical …

The mitochondrial permeability transition pore (mPTP) plays a critical role in the
pathogenesis of cardiovascular diseases, including ischemia/reperfusion injury. Although …

Under conditions of mitochondrial calcium overload, especially when accompanied by
oxidative stress, elevated phosphate concentrations and adenine nucleotide depletion, a …

The mitochondrial permeability transition pore (mPTP) opening plays a critical role in
mediating cell death during ischemia/reperfusion (I/R) injury. Our previous studies have …

Mitochondria play a central role in heart energy metabolism and Ca2+ homeostasis and are
involved in the pathogenesis of many forms of heart disease. The body of knowledge on …

Growing number of studies provide strong evidence that the mitochondrial permeability
transition pore (PTP), a non-selective channel in the inner mitochondrial membrane, is …

The mitochondrial permeability transition pore (MPTP) plays a key role in cell death,
especially necrosis, and mediates the injury tissues such as the heart and brain experience …

Inhibition of the mitochondrial permeability transition pore (PTP) has proved to be an
effective strategy for preventing oxidative stress-induced cell death, and the pore represents …