Initial studies conducted on the neuroprotective effects of minocycline, a second-generation
tetracycline, in experimental models of neurodegeneration gave promising results. However …

Minocycline, a clinically used tetracycline for over 40 years, crosses the blood–brain barrier
and prevents caspase up‐regulation. It reduces apoptosis in mouse models of Huntington's …

Minocycline is a widely used tetracycline antibiotic. For decades, it has been used to treat
various gram‐positive and gram‐negative infections. Minocycline was recently shown to …

Minocycline hydrochloride (MH), a semi-synthetic tetracycline derivative, is a clinically
available antibiotic and anti-inflammatory drug that also exhibits potent neuroprotective …

Minocycline has been demonstrated to be neuroprotective after spinal cord injury (SCI).
However, the cellular consequences of minocycline treatment on the secondary injury …

Minocycline ameliorates deficits in models of acute and chronic neurological diseases, but
many publications do not replicate these results. We tested the hypothesis that a key factor …

Spinal cord injury (SCI) is known as a debilitating condition which usually occurs due to
traumas to the spine. However, the injury could also occur during clinical interventions such …

Minocycline is a member of the tetracycline class of molecules with broad-spectrum
antibiotic activity. The unique properties of minocycline result in increased tissue distribution …

Objective Minocycline, a second-generation tetracycline-class antibiotic, has been well
established to exert a neuroprotective effect in animal models and neurodegenerative …

The lack of robust treatment options available for neurodegenerative diseases, stroke, and
central nervous system (CNS) trauma, all of which often involve both inflammation and …