p53-Dependent and-independent functions of the Arf tumor suppressor
CJ Sherr, D Bertwistle, W Den Besten… - Cold Spring Harbor …, 2005 - symposium.cshlp.org
Abstract The Ink4a-Arf locus encodes two closely wedded tumor suppressor proteins (p16
Ink4a and p19 Arf) that inhibit cell proliferationby activating Rb and p53, respectively. With …
Ink4a and p19 Arf) that inhibit cell proliferationby activating Rb and p53, respectively. With …
Arf induces p53-dependent and-independent antiproliferative genes
ML Kuo, EJ Duncavage, R Mathew, W Den Besten… - Cancer Research, 2003 - AACR
The tumor suppressor p19Arf (p14ARF in humans), encoded by the Ink4a/Arf locus, is
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
T Kamijo, JD Weber, G Zambetti… - Proceedings of the …, 1998 - National Acad Sciences
The INK4a-ARF locus encodes two proteins, p16INK4a and p19ARF, that restrain cell
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice
B Eymin, C Leduc, JL Coll, E Brambilla, S Gazzeri - Oncogene, 2003 - nature.com
Until recently, the ability of ARF (human p14 ARF, murine p19 ARF) tumour-suppressor
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
Tumor Spectrum in ARF-deficient Mice
T Kamijo, S Bodner, E van de Kamp, DH Randle… - Cancer research, 1999 - AACR
The p19ARF product of the INK4a/ARF locus is induced in response to potentially oncogenic
hyperproliferative signals and activates p53 by interfering with its negative regulator, Mdm2 …
hyperproliferative signals and activates p53 by interfering with its negative regulator, Mdm2 …
Human tumor suppressor ARF impedes S-phase progression independent of p53
WG Yarbrough, M Bessho, A Zanation, JE Bisi, Y Xiong - Cancer research, 2002 - AACR
Using alternative reading frames, the human ARF-INK4a locus encodes two unrelated
proteins that both function in tumor suppression. p16INK4a maintains the retinoblastoma …
proteins that both function in tumor suppression. p16INK4a maintains the retinoblastoma …
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses
The tumour suppressor ARF is specifically required for p53 activation under oncogenic
stress,,,,,. Recent studies showed that p53 activation mediated by ARF, but not that induced …
stress,,,,,. Recent studies showed that p53 activation mediated by ARF, but not that induced …
Human ARF binds E2F1 and inhibits its transcriptional activity
B Eymin, L Karayan, P Séité, C Brambilla, E Brambilla… - Oncogene, 2001 - nature.com
The INK4a/ARF locus which is frequently inactivated in human tumours encodes two
different tumour suppressive proteins, p16 INK4a and ARF. p16 INK4a is a major component …
different tumour suppressive proteins, p16 INK4a and ARF. p16 INK4a is a major component …
Arf tumor suppressor promoter monitors latent oncogenic signals in vivo
F Zindy, RT Williams, TA Baudino… - Proceedings of the …, 2003 - National Acad Sciences
Induction of the Arf tumor suppressor gene by elevated thresholds of mitogenic signals
activates a p53-dependent transcriptional response that triggers either growth arrest or …
activates a p53-dependent transcriptional response that triggers either growth arrest or …
E2F and Ras Synergize in Transcriptionally Activating p14ARF Expression
E Berkovich, Y Lamed, D Ginsberg - Cell Cycle, 2003 - Taylor & Francis
The INK4a/ARF locus, which is frequently inactivated in human tumors, encodes two distinct
tumor suppressive proteins, ARF and p16INK4a. ARF stabilizes and activates p53 by …
tumor suppressive proteins, ARF and p16INK4a. ARF stabilizes and activates p53 by …