Astragalin exerted antidepressant-like action through SIRT1 signaling modulated NLRP3 inflammasome deactivation

Y Tong, H Fu, C Xia, W Song, Y Li, J Zhao… - ACS chemical …, 2020 - ACS Publications
Inflammation plays a key role in the pathogenesis of depression and antidepressant
therapies. Astragalin (AST) is a bioactive flavonoid that possesses an anti-inflammatory …

Astragaloside IV ameliorates neuroinflammation-induced depressive-like behaviors in mice via the PPARγ/NF-κB/NLRP3 inflammasome axis

M Song, J Ruan, R Zhang, J Deng, Z Ma… - Acta Pharmacologica …, 2018 - nature.com
Major depressive disorder is a common but devastating mental disorder, and recent
evidence shows that neuroinflammation may play a pivotal role in the etiology of depression …

Astragalin attenuates depression-like behaviors and memory deficits and promotes M2 microglia polarization by regulating IL-4R/JAK1/STAT6 signaling pathway in a …

G Yao, Z Bai, J Niu, R Zhang, Y Lu, T Gao… - Psychopharmacology, 2022 - Springer
Rationale Neuroinflammation can be alleviated via M2 microglia polarization, which could
promote the recovery of perimenopausal depression. Astragalin (AST) possesses anti …

Agomelatine rescues lipopolysaccharide-induced neural injury and depression-like behaviors via suppression of the Gαi-2-PKA-ASK1 signaling pathway

T Lan, Y Wu, Y Zhang, S Li, Z Zhu, L Wang… - Journal of …, 2022 - Springer
Background Agomelatine has been shown to be effective in the treatment of depression, but
the molecular mechanisms underlying its antidepressant effects have yet to be elucidated …

The role and mechanism of NLRP3 inflammasome-mediated astrocyte activation in dehydrocorydaline against CUMS-induced depression

Y Fang, H Guo, Q Wang, C Liu, S Ge… - Frontiers in …, 2022 - frontiersin.org
Background: Depression is a common and potentially life-threatening mental illness, and
currently, there is a lack of effective treatment. It has been reported that dehydrocorydaline …

Antidepressive effect of arctiin by attenuating neuroinflammation via HMGB1/TLR4-and TNF-α/TNFR1-mediated NF-κB activation

X Xu, XY Zeng, YX Cui, YB Li, JH Cheng… - ACS chemical …, 2020 - ACS Publications
Inflammation is a potential factor in the pathophysiology of depression. A traditional Chinese
herbal medicine, arctiin, and its aglycone, arctigenin, are the major bioactive components in …

Acacetin improves cognitive function of APP/PS1 Alzheimer's disease model mice via the NLRP3 inflammasome signaling pathway

J Bu, Y Zhang, Y Mahan, S Shi, X Wu… - Translational …, 2022 - degruyter.com
Abstract Background Acacetin (5, 7-dihydroxy-4′-methoxyflavone), one of the main
extractions from Saussurea involucrata, has anti-inflammatory effects. Our previous study …

Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption

Z Qin, DD Shi, W Li, D Cheng, YD Zhang… - Journal of …, 2023 - Springer
Objectives Neuroinflammation has been suggested that affects the processing of
depression. There is renewed interest in berberine owing to its anti-inflammatory effects …

(−)‐Epigallocatechin gallate alleviates chronic unpredictable mild stress‐induced depressive symptoms in mice by regulating the mTOR autophagy pathway and …

Y Zhang, H Wu, C Xu, S Li, Y Hu, Z Zhang… - Food Science & …, 2024 - Wiley Online Library
Depression is a global public health issue that is widely studied due to the large number of
people it affects and its serious consequences. Clinical studies have shown that regular tea …

Yamogenin Exhibits Antidepressant-like Effects via Inhibition of ER Stress and Microglial Activation in LPS-Induced Mice

PL Chen, GH Xu, M Li, JY Zhang, J Cheng… - ACS Chemical …, 2023 - ACS Publications
Depression is a multifaceted psychiatric disorder that affects a significant number of
individuals worldwide, and its pathophysiology encompasses a variety of mechanisms …