The complement system consists of about 35–40 proteins and glycoproteins present in
blood plasma or on cell surfaces. Its main biological function is to recognise “foreign” …

The complement (C) inflammatory cascade is part of the phylogenetically ancient innate
immune response and is crucial to our natural ability to ward off infection. It has three critical …

The complement system plays a key role in several dermatological diseases. Overactivation,
deficiency, or abnormality of the control proteins are often related to a skin disease …

Complement receptors are expressed on cells of the innate and the adaptive immune
system. They play important roles in pathogen and danger sensing as they translate the …

Autoantibodies to complement components are associated with various diseases. Anti-C1q
antibodies are present in all patients with hypocomplementemic urticarial vasculitis, but also …

The complement system was discovered almost a century ago as an important effector in
antibody-dependent killing of microorganisms. Since this early period much was learned …

Objectives The complement system is an important component of innate immunity. The
alternative pathway (AP) amplification loop is considered an essential feed forward …

The complement system is a key component of innate immunity, acting to protect the host
from micro-organisms such as bacteria and other “foreign” threats, including tumor cells …

Complement is involved in the pathogenesis of systemic lupus erythematosus (SLE) in
multiple ways and may act as both friend and foe. Inherited homozygous deficiency of one of …

the complement system is a critical component of the innate and adaptive immune system
(reviewed by Volanakis, 1998). Complement plays an important role in microbial killing, and …