The endoplasmic reticulum (ER) is the principal cellular organelle in which correct folding
and maturation of transmembrane, secretory, and ER-resident proteins occur. Research …

The endoplasmic reticulum (ER) functions to properly fold and process secreted and
transmembrane proteins. Environmental and genetic factors that disrupt ER function cause …

Cellular mechanisms governing redox homeostasis likely involve their integration with other
stresses. Endoplasmic reticulum (ER) stress triggers complex adaptive or proapoptotic …

A variety of debilitating diseases including diabetes, Alzheimer's, Huntington's, Parkinson's,
and prion-based diseases are linked to stress within the endoplasmic reticulum (ER). Using …

The endoplasmic reticulum (ER) is a dynamic intracellular organelle with multiple functions
essential for cellular homeostasis, development, and stress responsiveness. In response to …

Disturbances in the normal functions of the ER lead to an evolutionarily conserved cell
stress response, the unfolded protein response, which is aimed initially at compensating for …

The endoplasmic reticulum (ER) and mitochondria form physical interactions involved in the
regulation of biologic functions including mitochondrial bioenergetics and apoptotic …

The endoplasmic reticulum (ER) is recognized primarily as the site of synthesis and folding
of secreted and membrane‐bound proteins. The ER provides stringent quality control …

Stress pathways monitor intracellular systems and deploy a range of regulatory mechanisms
in response to stress. One of the best-characterized pathways, the UPR (unfolded protein …

The endoplasmic reticulum (ER) is a dynamic organelle that is essential for multiple cellular
functions. During cellular stress conditions, including nutrient deprivation and dysregulation …