The folding process is an important step in protein synthesis for the functional shape or
conformation of the protein. The endoplasmic reticulum (ER) is the main organelle for the …

Stress within the endoplasmic reticulum (ER) induces a sophisticated network of pathways
termed the unfolded protein response (UPR), which is mediated through the ER …

Over the past years, knowledge and evidence about the existence of crosstalks between
cellular organelles and their potential effects on survival or cell death have been constantly …

Cells activate protective mechanisms to overcome stressful conditions that threaten cellular
homeostasis, including imbalances in calcium, redox, and nutrient levels. Endoplasmic …

Endoplasmic reticulum (ER) calcium signaling is implicated in a myriad of coordinated
cellular processes. The ER calcium content is tightly regulated as it allows a favorable …

Unfolded stress response (UPR) is a conserved cellular pathway involved in protein quality
control to maintain homeostasis under different conditions and disease states characterized …

Execution of fundamental cellular functions demands regulated protein folding homeostasis.
Endoplasmic reticulum (ER) is an active organelle existing to implement this function by …

The unfolded protein response (UPR) is an adaptive stress response in which cells recover
from the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) …

The endoplasmic reticulum (ER) is the site of folding of membrane and secreted proteins in
the cell. Physiological or pathological processes that disturb protein folding in the …

Numerous genetic and environmental insults impede the ability of cells to properly fold and
posttranslationally modify secretory and transmembrane proteins in the endoplasmic …