The metabolism of heroin was investigated in mice using a method which simultaneously
measured heroin and two of its biotransformation products, 6-monacetylmorphine (MAM) …

In a previous study (Way et al., 1960), we reported that heroin is rapidly hydrolyzed in the
body to two products-namely, 6-monoacetylmorphine (MAM) and morphine (figure 1). The …

ABSTRACT YEH, S.\'., CV GORODETZKY ANt) RL McQu INN: Urinary excretion of heroin
and its metabolites in man. J. Pharmacol. Exp. Ther. 196: 249-256, 1976. The purpose of this …

Heroin is currently being advocated by some as a superior therapeutic agent for use in
terminal illness. However, a review of the literature on heroin presently available does not …

The effects of heroin given to human subjects by continuous intravenous infusion are
described. Progressive CNS depression eventually required reversal with levallorphan …

METHOD. Subjects and medications. Twenty-four healthy, nonaddicted, college men
between the ages of 21 and 30 were used as subjects. Each was given morphine …

In the past four decades the results of thousands of experiments with morphine on animals
have been published, reflecting the many attempts to elucidate the metabolism of morphine …

We measured blood concentrations of heroin and its active metabolites, 6-acetylmorphine
and morphine, serially in 11 patients with chronic pain (9 of whom had cancer) after …

METHODS. Single dose study. Eleven volunteer subjects serving sentences for violation of
federal narcotic laws were employed in this study. All subjects gave a long history of opiate …

A kinetic study of heroin hydrolysis in alkaline aqueous solution at room temperature was
conducted by a gas chromatographic method to measure the consecutive reactions of …