Epidemiological studies have shown that the environment experienced in early life can
'programme'susceptibility to later disease. Furthermore, there is increasing evidence that …

The ability of environmental factors to promote a phenotype or disease state not only in the
individual exposed but also in subsequent progeny for successive generations is termed …

Abstract The Developmental Origins of Health and Disease hypothesis describes how early
life environmental factors influence development in a way that impacts later health and …

Mammalian experiments provide clear evidence of male line transgenerational effects on
health and development from paternal or ancestral early-life exposures such as diet or …

There is ample evidence that subtle changes in the early environment, not restricted to the
fetal period but expanded to the plastic phase of early development, influence adulthood …

The developmental origins of health and disease (DOHaD) hypothesis predicts that
environmental exposures experienced early in life have the potential to modify the risk …

Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

Extensive human epidemiologic and animal model data indicate that during critical periods
of prenatal and postnatal mammalian development, nutrition and other environmental stimuli …

The periconceptional period of mammalian development has been identified as an early
'developmental window'during which environmental conditions may influence the pattern of …

Traditionally, we understand that individual phenotypes result primarily from inherited
genetic variants together with environmental exposures. However, many studies showed …