Traditionally, we understand that individual phenotypes result primarily from inherited
genetic variants together with environmental exposures. However, many studies showed …

Epidemiological evidence increasingly suggests that environmental exposures early in
development have a role in susceptibility to disease in later life. In addition, some of these …

We all know our environment affects our risk of disease. But importantly, the health
consequences of environmental exposures depend not only on their severity but also on …

The field of Developmental Origins of Health and Disease (DOHaD) seeks to understand the
relationships between early-life environmental exposures and long-term health and disease …

Environmental exposures such as toxicants, nutrition and stress have been shown to
promote the epigenetic transgenerational inheritance of disease susceptibility. Endocrine …

What are the effects of our environment on human development and the next generation?
Numerous studies have provided ample evidence that a healthy environment and lifestyle of …

Background There is much evidence to suggest that risk for common clinical disorders
begins in foetal life. Exposure to environmental risk factors however is often not random …

Several lines of evidence point to the early origin of adult onset disease. A key question is:
what are the mechanisms that mediate the effects of the early environment on our health …

The importance of developmental factors in influencing the risk of later-life disease has a
strong evidence base derived from multiple epidemiological, clinical and experimental …

Suboptimal intrauterine conditions, including poor nutrition, during critical periods of growth
may lead to lifelong changes in the body's organs and tissues, thus providing a …