Both human and animal studies indicate that environmental exposures experienced during
early life can robustly influence risk for adult disease. Moreover, environmental exposures …

Despite a wealth of underpinning experimental support, there has been considerable
resistance to the concept that environmental factors acting early in life (usually in fetal life) …

Accumulating evidence suggests that the intrauterine environment can have an impact on
long-term offspring health, so-called 'fetal programming'. A number of environmental …

Numerous studies in humans and in animal models have demonstrated that exposure to
adverse environmental conditions in early life results in long-term structural and functional …

BACKGROUND The concept of developmental programming suggests that the early life
environment influences offspring characteristics in later life, including the propensity to …

The current concept of fetal origins of adult diseases describes in utero programming, or
adaptation to a spectrum of adverse environmental conditions that ultimately leads to …

Environmental insults, such as exposure to toxicants or nutritional abnormalities, can lead to
epigenetic changes that are in turn related to increased susceptibility to disease. The focus …

Developmental origins of health and disease (DOHaD) is the study of how the early life
environment can impact the risk of chronic diseases from childhood to adulthood and the …

Though there are multiple routes through which parents can influence their offspring, recent
studies of environmentally induced epigenetic variation have highlighted the role of non …

Epidemiological and animal studies show that small changes in the developmental
environment can induce phenotypic changes affecting an individual's responses to their …