That there is a heritable or familial component of susceptibility to chronic non‐communicable
diseases such as type 2 diabetes, obesity and cardiovascular disease is well established …

Exposure to different environmental factors, social and socioeconomic factors promotes
development of the early-life adversity (ELA) phenotype. The persistence of this phenotype …

This review focuses on how environmental factors through epigenetics modify disease risk
and health outcomes. Major epigenetic events, such as histone modifications, DNA …

The concept emerging from Professor David Barker's seminal research on the
developmental origins of later-life disease has progressed in many directions since it was …

The earliest indications for paternally induced transgenerational effects from the
environment to future generations were based on a small number of long-term …

It has been approximately 30 years since the seminal discoveries of David Barker and his
colleagues, and research is beginning to unravel the mechanisms that underlie …

A wide range of developmental, nutritional, environmental, and social factors affect the
biological activities of epigenetic mechanisms. These factors change spatiotemporal …

Epigenetics is a rapidly evolving scientific field of inquiry examining how a wide range of
environmental, social, and nutritional exposures can dramatically control how genes are …

There is now considerable evidence that elements of the heritable or familial component of
disease susceptibility are transmitted by nongenomic means, and that environmental …

Adverse insults during intrauterine life can result in permanent changes in the physiology
and metabolism of the offspring, which in turn leads to an increased risk of disease in …