LOX-1 and atherosclerotic-related diseases

P Jin, S Cong - Clinica chimica acta, 2019 - Elsevier
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), a scavenger receptor of
oxidized low-density lipoprotein (ox-LDL) found in various cells, plays a crucial role in the …

LOX-1 in atherosclerosis and myocardial ischemia: biology, genetics, and modulation

NVK Pothineni, SK Karathanasis, Z Ding… - Journal of the American …, 2017 - jacc.org
Lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), one of the scavenger
receptors for oxidized low-density lipoprotein cholesterol (ox-LDL), plays a crucial role in the …

The discovery of LOX-1, its ligands and clinical significance

R Yoshimoto, Y Fujita, A Kakino, S Iwamoto… - … drugs and therapy, 2011 - Springer
LOX-1 is an endothelial receptor for oxidized low-density lipoprotein (oxLDL), a key
molecule in the pathogenesis of atherosclerosis. The basal expression of LOX-1 is low but …

Soluble lectin‐like oxidized low density lipoprotein receptor‐1 as a biochemical marker for atherosclerosis‐related diseases

A Pirillo, AL Catapano - Disease markers, 2013 - Wiley Online Library
Lectin‐like oxidized low density lipoprotein receptor‐1 (LOX‐1), the main oxidized low‐
density lipoprotein (OxLDL) in endothelial cells, is upregulated in atherosclerotic lesions and …

LOX-1: regulation, signaling and its role in atherosclerosis

AJ Kattoor, A Goel, JL Mehta - Antioxidants, 2019 - mdpi.com
Atherosclerosis has long been known to be a chronic inflammatory disease. In addition,
there is intense oxidative stress in atherosclerosis resulting from an imbalance between the …

Atherosclerosis and the lectin-like oxidized low-density lipoprotein scavenger receptor

RS Vohra, JE Murphy, JH Walker… - Trends in cardiovascular …, 2006 - Elsevier
The Lectin-like OXidized low-density lipoprotein scavenger receptor (LOX-1) is implicated in
vascular inflammation and atherosclerotic plaque initiation, progression, and destabilization …

Role of LOX-1 (lectin-like oxidized low-density lipoprotein receptor 1) as a cardiovascular risk predictor: mechanistic insight and potential clinical use

J Barreto, SK Karathanasis, A Remaley… - … , and vascular biology, 2021 - Am Heart Assoc
Atherosclerosis, the underlying cause of cardiovascular disease (CVD), is a worldwide
cause of morbidity and mortality. Reducing ApoB-containing lipoproteins—chiefly, LDL (low …

High levels of soluble lectinlike oxidized low‐density lipoprotein receptor‐1 are associated with carotid plaque inflammation and increased risk of ischemic stroke

H Markstad, A Edsfeldt, I Yao Mattison… - Journal of the …, 2019 - Am Heart Assoc
Background When the lectinlike oxidized low‐density lipoprotein (ox LDL) receptor‐1 (LOX‐
1), a scavenger receptor for ox LDL, binds ox LDL, processes leading to endothelial …

Soluble lectin-like oxidized low-density lipoprotein receptor-1 predicts premature death in acute coronary syndromes

S Kraler, FA Wenzl, G Georgiopoulos… - European heart …, 2022 - academic.oup.com
Aims The lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1) and its shedding
product [soluble LOX-1 (sLOX-1)] are implicated in atherosclerotic cardiovascular disease …

[PDF][PDF] LOX-1-mediated effects on vascular cells in atherosclerosis

DA Chistiakov, AN Orekhov… - Cellular Physiology and …, 2016 - karger.com
In healthy arteries, expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX-
1) is almost undetectable. However, in proatherogenic conditions, LOX-1 is markedly …