Cellular senescence is a cell fate involving cell cycle arrest, resistance against apoptosis,
and the development of a secretome that can be pro-inflammatory. In aging and obesity …

The increasing life expectancy of the world population has become an economic and global
public health problem. Increased life expectancy tracks with a higher incidence of multiple …

Senotherapy is an antiageing strategy. It refers to selective killing of senescent cells by
senolytic agents, strengthening the activity of immune cells that eliminate senescent cells or …

Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

Cellular senescence is a state of stable cell cycle arrest that is known to be elicited in
response to different stresses or forms of damage. Senescence limits the replication of old …

Life expectancy has increased substantially over the last few decades, leading to a
worldwide increase in the prevalence and burden of aging-associated diseases. Recent …

Originally identified as an outcome of continuous culture of primary cells, cellular
senescence has moved beyond the culture dish and is now a bona fide driver of aging and …

Cellular senescence is a heterogeneous process guided by genetic, epigenetic and
environmental factors, characterizing many types of somatic cells. It has been suggested as …

Ageing and diabetes lead to similar organ dysfunction that is driven by parallel molecular
mechanisms, one of which is cellular senescence. The abundance of senescent cells in …

Cellular senescence is a permanent state of cell cycle arrest that promotes tissue
remodeling during development and after injury, but can also contribute to the decline of the …