The musculoskeletal system supports the movement of the entire body and provides blood
production while acting as an endocrine organ. With aging, the balance of bone …

Aging is inevitable. Along with reduced ability to maintain the homeostasis of various
biological processes, aging gradually deteriorates overall health. Extensive research on the …

The progression of physiological ageing is driven by intracellular aberrations including
telomere attrition, genomic instability, epigenetic alterations and loss of proteostasis. These …

Recent discoveries are redefining our view of cellular senescence as a trigger of tissue
remodelling that acts during normal embryonic development and upon tissue damage. To …

Cellular senescence is an anti‐proliferative program that restricts the propagation of cells
subjected to different kinds of stress. Cellular senescence was initially described as a cell …

Physical function declines in old age, portending disability, increased health expenditures,
and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these …

Senescence is a state of permanent cell cycle arrest. Cellular senescence can promote
tissue remodelling but can negatively affect regenerative capacities of tissues and contribute …

Aging is the result of a gradual functional decline at the cellular, and ultimately, organismal
level, resulting in an increased risk of developing a variety of chronic illnesses, such as …

Senescent cells accumulate with aging and at etiological sites of multiple diseases,
including those accounting for most morbidity, mortality, and health costs. Senescent cells …

Ageing is associated with the functional decline of all tissues and a striking increase in many
diseases. Although ageing has long been considered a one-way street, strategies to delay …