The reduced risk of dementia in high-educated individuals has been suggested to reflect
brain reserve capacity. In the present study, we determined the association between integrity …

Given that the life expectancy in our society is increasing, a central question is how older
individuals can live these additional years of life in a state of good health and well-being …

The low-educated elderly are a vulnerable population in whom studying the role of white
matter integrity on memory may provide insights for understanding how memory declines …

Background: The biological basis of cognitive ageing is unknown. One underlying process
might be disruption of white matter tracts connecting cortical regions. White matter lesions …

Declines in cognitive function in normal aging have been linked to decreases in white matter
(WM) integrity, measured non-invasively using diffusion tensor imaging (DTI). The present …

Identifying predictors of cognitive decline in old age helps us understand its mechanisms
and identify those at greater risk. Here, we examined how cognitive change from ages 11 to …

Background: Evidence suggests birth cohort differences in cognitive performance of older
adults. Proxies of cognitive reserve (CR), such as educational attainment and occupational …

In this work we investigate relationships between white matter lesion (WML) intensity and
measures of cognitive ability obtained in youth and old age in the Lothian Birth Cohort 1936 …

Background The increased focus on preclinical Alzheimer's disease (AD) necessitates an
understanding of how general biomarkers of neuronal injury and AD‐specific biomarkers …

Abstract Introduction Previous Alzheimer's disease and related dementias (AD/ADRD)
research studies have illustrated the significance of studying alterations in white matter …