Mitochondrial function in vivo evaluated by NADH fluorescence: from animal models to human studies
A Mayevsky, GG Rogatsky - American journal of physiology …, 2007 - journals.physiology.org
Normal mitochondrial function is a critical factor in maintaining cellular homeostasis in
various organs of the body. Due to the involvement of mitochondrial dysfunction in many …
various organs of the body. Due to the involvement of mitochondrial dysfunction in many …
Measurement of mitochondrial NADH and FAD autofluorescence in live cells
F Bartolomé, AY Abramov - Mitochondrial Medicine: Volume I, Probing …, 2015 - Springer
In the process of energy production, mitochondrial networks are key elements to allow
metabolism of substrates into ATP. Many pathological conditions have been associated with …
metabolism of substrates into ATP. Many pathological conditions have been associated with …
Oxidation–reduction states of NADH in vivo: from animals to clinical use
A Mayevsky, B Chance - Mitochondrion, 2007 - Elsevier
Mitochondrial dysfunction is part of many pathological states in patients, such as sepsis or
stroke. Presently, the monitoring of mitochondrial function in patients is extremely rare, even …
stroke. Presently, the monitoring of mitochondrial function in patients is extremely rare, even …
In vivo NADH fluorescence
C Ince, J Coremans, HA Bruining - Oxygen transport to tissue XIV, 1992 - Springer
Reduced nicotinamide adenine dinucleotide (NADH) offers one of the main means to
transfer energy from the tricarboxylic acid cycle to the respiratory chain in the mitochondria …
transfer energy from the tricarboxylic acid cycle to the respiratory chain in the mitochondria …
NADH autofluorescence—a marker on its way to boost bioenergetic research
PM Schaefer, S Kalinina, A Rueck… - Cytometry Part …, 2019 - Wiley Online Library
More than 60 years ago, the idea was introduced that NADH autofluorescence could be
used as a marker of cellular redox state and indirectly also of cellular energy metabolism …
used as a marker of cellular redox state and indirectly also of cellular energy metabolism …
[HTML][HTML] Investigating mitochondrial redox state using NADH and NADPH autofluorescence
TS Blacker, MR Duchen - Free Radical Biology and Medicine, 2016 - Elsevier
The redox states of the NAD and NADP pyridine nucleotide pools play critical roles in
defining the activity of energy producing pathways, in driving oxidative stress and in …
defining the activity of energy producing pathways, in driving oxidative stress and in …
Metabolic imaging using two-photon excited NADH intensity and fluorescence lifetime imaging
J Vergen, C Hecht, LV Zholudeva… - Microscopy and …, 2012 - academic.oup.com
Metabolism and mitochondrial dysfunction are known to be involved in many different
disease states. We have employed two-photon fluorescence imaging of intrinsic …
disease states. We have employed two-photon fluorescence imaging of intrinsic …
Intracellular coenzymes as natural biomarkers for metabolic activities and mitochondrial anomalies
AA Heikal - Biomarkers in medicine, 2010 - Future Medicine
Mitochondria play a pivotal role in energy metabolism, programmed cell death and oxidative
stress. Mutated mitochondrial DNA in diseased cells compromises the structure of key …
stress. Mutated mitochondrial DNA in diseased cells compromises the structure of key …
Mitochondrial NADH fluorescence is enhanced by complex I binding
Mitochondrial NADH fluorescence has been a useful tool in evaluating mitochondrial
energetics both in vitro and in vivo. Mitochondrial NADH fluorescence is enhanced several …
energetics both in vitro and in vivo. Mitochondrial NADH fluorescence is enhanced several …
[HTML][HTML] Two-photon autofluorescence dynamics imaging reveals sensitivity of intracellular NADH concentration and conformation to cell physiology at the single-cell …
Reduced nicotinamide adenine dinucleotide, NADH, is a major electron donor in the
oxidative phosphorylation and glycolytic pathways in cells. As a result, there has been …
oxidative phosphorylation and glycolytic pathways in cells. As a result, there has been …