Direct and indirect air particle cytotoxicity in human alveolar epithelial cells

NS Orona, F Astort, GA Maglione, PHN Saldiva… - Toxicology in Vitro, 2014 - Elsevier
Air particulate matter has been associated with adverse impact on the respiratory system
leading to cytotoxic and proinflammatory effects. The biological mechanisms behind these …

[HTML][HTML] The combined effects of physicochemical properties of size-fractionated ambient particulate matter on in vitro toxicity in human A549 lung epithelial cells

US Akhtar, N Rastogi, RD McWhinney, B Urch… - Toxicology Reports, 2014 - Elsevier
Epidemiological and toxicological studies have suggested that the health effects associated
with exposure to particulate matter (PM) are related to the different physicochemical …

[HTML][HTML] The role and potential pathogenic mechanism of particulate matter in childhood asthma: a review and perspective

X Xu, J Zhang, X Yang, Y Zhang, Z Chen - Journal of Immunology …, 2020 - hindawi.com
Asthma, the most common chronic respiratory disease in children, affects numerous people
worldwide. Accumulating evidence suggests that exposure to high levels of particulate …

Determinants of the proinflammatory action of ambient particulate matter in immortalized murine macrophages

C Guastadisegni, FJ Kelly, FR Cassee… - Environmental …, 2010 - ehp.niehs.nih.gov
Background Proximity to traffic-related pollution has been associated with poor respiratory
health in adults and children. Objectives We wished to test the hypothesis that particulate …

Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin

A CP Elder, R Gelein, J N. Finkelstein, C Cox… - Inhalation …, 2000 - Taylor & Francis
Epidemiological studies demonstrate associations between increasing levels of ambient
particles and morbidity in the elderly with cardiopulmonary disease. Such findings have …

Size-dependent proinflammatory effects of ultrafine polystyrene particles: a role for surface area and oxidative stress in the enhanced activity of ultrafines

DM Brown, MR Wilson, W MacNee, V Stone… - Toxicology and applied …, 2001 - Elsevier
Studies into the effects of ultrafine particles in the lung have shown adverse effects
considered to be due in part to the particle size. Air pollution particles (PM10) are associated …

[HTML][HTML] Particulate air pollution: major research methods and applications in animal models

Y Shang, Q Sun - Environmental disease, 2018 - journals.lww.com
Ambient air pollution is composed of a heterogeneous mixture of gaseous and solid particle
compounds in which primary particles are emitted directly into the atmosphere, such as …

Response of human alveolar macrophages to ultrafine, fine, and coarse urban air pollution particles

S Becker, JM Soukup, C Sioutas… - Experimental lung …, 2003 - Taylor & Francis
In the lower airways, macrophages are important regulators of inflammation and
indispensable in their antimicrobial activities. Thus, air pollution particles, which modulate …

Ultrafine particle–lung interactions: does size matter?

WG Kreyling, M Semmler-Behnke… - Journal of Aerosol …, 2006 - liebertpub.com
Epidemiological studies continue to indicate associations between exposure to increased
concentrations of ambient fine and ultrafine particles and adverse health effects in …

Allergic airway inflammation is differentially exacerbated by daytime and nighttime ultrafine and submicron fine ambient particles: heme oxygenase-1 as an indicator …

CM Carosino, KJ Bein, LE Plummer… - Journal of Toxicology …, 2015 - Taylor & Francis
Ambient particulate matter (PM) originates from a range of sources and differs in
composition with respect to season, time of day, and particle size. In this study, ambient PM …