The diagnosis of a mental disorder generally depends on clinical observations and
phenomenological symptoms reported by the patient. The definition of a given diagnosis is …

Depression is apparently the most common psychiatric disease among the mood disorders
affecting about 10% of the adult population. The etiology and pathogenesis of depression …

Major depression disorder (MDD) is a debilitating mental illness with significant morbidity
and mortality. Despite the growing number of studies that have emerged, the precise …

Animal models of depression are certainly needed but the question in the title has been
raised owing to the controversies in the interpretation of the readout in a number of tests, to …

Animal models of human disease have proven of considerable value in elucidating basic
pathophysiological mechanisms and in developing novel treatments. However, modelling …

Depression is a common psychiatric disorder, with diverse symptoms and high comorbidity
with other brain dysfunctions. Due to this complexity, little is known about the neural and …

Over recent decades, encouraging preclinical evidence using rodent models pointed to
innovative pharmacological targets to treat major depressive disorder. However, subsequent …

Mood disorders such as depression are the most prevalent diseases amongst psychiatric
disorders and a leading cause for disability worldwide. Modelling mood disorders in animals …

Depression is a chronic, recurring and potentially life-threatening illness that affects up to
20% of the population across the world. Despite its prevalence and considerable impact on …

Overlapping characteristics between human depressive phenotypes and mouse behaviors
has led to the creation of mouse models that aim to investigate the pathophysiology and …