Despite the fact that hundreds of genes are known to affect fertility in animal models,
relatively little is known about genes that influence natural fertility in humans. To broadly …

STUDY QUESTION Are the four candidate loci (rs7867029, rs7174015, rs12870438 and
rs724078) for human male fertility traits, identified in a genome-wide association study …

Approximately 1 in 6 couples in the Western world is not able to conceive spontaneously
after 1 year of unprotected intercourse; in nearly half of these couples, the male partner has …

A thorough understanding of the genetic basis of male infertility has eluded researchers in
spite of significant efforts to identify novel genetic causes of the disease, particularly over the …

Understanding the genetic basis of idiopathic male infertility has long been the focus of
many researchers. Numerous recent studies have attempted to identify relevant single …

Male infertility represents one of the clearest examples of a complex disease with a
substantial genetic basis. Numerous male mouse models, mutation screening and …

Many genetic polymorphisms have been studied extensively to elucidate their role in the
pathophysiology of male infertility. This article presents a review of the literature following a …

Male infertility affects a large proportion of the population. In spite of the magnitude of the
problem and the considerable research effort that has been made to understand its causes …

Male infertility is an extraordinarily common problem affecting 1 in 25 men. Despite active
research, the underlying causal factors remain unknown in a large percentage (40%) of …

BACKGROUND In spite of tremendous efforts by a number of groups, the search for single
nucleotide polymorphisms (SNPs) strongly associated with male factor infertility by means of …