In this study, treatment of C57BL/6J (wild type, WT) mice fed a high-fat diet (HFD) with
retinoic acid (RA) decreased body weight and subcutaneous and visceral fat content …

Background The exact mechanism of the protective role of Resveratrol (Res) in lipid
metabolism and oxidative stress is not well elucidated. The present study aimed to …

Objective Resveratrol (RSV) is the most studied natural compound that activates sirtuins,
which produce beneficial metabolic effects on lipid and glucose metabolism. The aim of the …

All‐trans retinoic acid (AtRA) is an active metabolite of vitamin A that influences many
biological processes in development, differentiation, and metabolism. AtRA functions …

Objective The adipose tissue–liver axis is a major regulator of the pathogenesis of
nonalcoholic fatty liver disease (NAFLD). Retinoic acid signaling plays an important role in …

Retinoic acid (RA), a bioactive metabolite of vitamin A, has shown therapeutic effects in liver
disease, and its effect in improving non-alcoholic fatty liver disease (NAFLD) is associated …

Background Studies have demonstrated that resveratrol (a natural polyphenol) and caloric
restriction activate Sirtuin-1 (SIRT1) and induce autophagy. Furthermore, autophagy is …

Mice deficient in small heterodimer partner (SHP) are protected from diet‐induced hepatic
steatosis resulting from increased fatty acid oxidation and decreased lipogenesis. The …

Recent studies in mice have shown that resveratrol can protect the liver from fat
accumulation induced by high fat diet. However, the exact mechanism is largely unknown …

Transgenic mice expressing dominant‐negative retinoic acid receptor (RAR) α specifically in
the liver exhibit steatohepatitis, which leads to the development of liver tumors. Although the …