Rapid uptake of gold nanorods by primary human blood phagocytes and immunomodulatory effects of surface chemistry

M Bartneck, HA Keul, S Singh, K Czaja, J Bornemann… - ACS …, 2010 - ACS Publications
Nanoparticle-based in vivo applications should consider the omnipresence of the
phagocytes in the bloodstream and tissue. We have studied the nanoparticle uptake …

Phagocytosis of biocompatible gold nanoparticles

Z Krpetic, F Porta, E Caneva, V Dal Santo, G Scarì - Langmuir, 2010 - ACS Publications
We report the evidence for the cellular uptake of gold nanoparticles via the phagocytosis
mechanism in murine macrophage cells strongly supported by TEM and optical microscopy …

Surface chemistry of gold nanoparticles mediates their exocytosis in macrophages

N Oh, JH Park - ACS nano, 2014 - ACS Publications
Significant quantities of synthetic nanoparticles circulating in the body are cleared and
retained for long periods of time in the resident macrophages of the mononuclear phagocytic …

Geometry and surface characteristics of gold nanoparticles influence their biodistribution and uptake by macrophages

MM Janát-Amsbury, A Ray, CM Peterson… - European Journal of …, 2011 - Elsevier
Spherical and rod-shaped gold nanoparticles with surface poly (ethylene glycol)(PEG)
chains were characterized for size, shape, charge, poly dispersity and surface plasmon …

Fluorescence‐encoded gold nanoparticles: library design and modulation of cellular uptake into dendritic cells

L Rodriguez‐Lorenzo, K Fytianos, F Blank… - Small, 2014 - Wiley Online Library
In order to harness the unique properties of nanoparticles for novel clinical applications and
to modulate their uptake into specific immune cells we designed a new library of homo‐and …

Macrophage Scavenger Receptor A Mediates The Uptake of Gold Colloids by Macrophages In Vitro

A França, P Aggarwal, EV Barsov, SV Kozlov… - …, 2011 - Taylor & Francis
Aims: While numerous studies have reported on nanoparticle uptake by phagocytic cells, the
mechanisms of this uptake are poorly understood. A metastudy of research focusing on …

Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake

CD Walkey, JB Olsen, H Guo, A Emili… - Journal of the …, 2012 - ACS Publications
Delivery and toxicity are critical issues facing nanomedicine research. Currently, there is
limited understanding and connection between the physicochemical properties of a …

Uptake efficiency of surface modified gold nanoparticles does not correlate with functional changes and cytokine secretion in human dendritic cells in vitro

K Fytianos, L Rodriguez-Lorenzo, MJD Clift… - … , Biology and Medicine, 2015 - Elsevier
Engineering nanoparticles (NPs) for immune modulation require a thorough understanding
of their interaction (s) with cells. Gold NPs (AuNPs) were coated with polyethylene glycol …

The interplay of size and surface functionality on the cellular uptake of sub-10 nm gold nanoparticles

Y Jiang, S Huo, T Mizuhara, R Das, YW Lee, S Hou… - ACS …, 2015 - ACS Publications
Correlation of the surface physicochemical properties of nanoparticles with their interactions
with biosystems provides key foundational data for nanomedicine. We report here the …

Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells

BD Chithrani, AA Ghazani, WCW Chan - Nano letters, 2006 - ACS Publications
We investigated the intracellular uptake of different sized and shaped colloidal gold
nanoparticles. We showed that kinetics and saturation concentrations are highly dependent …