Adult hematopoiesis depends on rare multipotent hematopoietic stem cells (HSCs) that self-
renew and give rise to progenitor cells, which differentiate to all blood lineages. The strict …

Although hematopoietic stem cells (HSCs) reside in hypoxic niches, the significance of
hypoxia signaling in HSCs remains unclear. In this issue of Cell Stem Cell, Takubo et …

Abstract Purpose of Review This review summarizes the role of hypoxia and hypoxia-
inducible factors (HIFs) in the regulation of stem cell biology, specifically focusing on …

Local hypoxia in hematopoietic stem cell (HSC) niches is thought to regulate HSC functions.
Hypoxia-inducible factor-1 (Hif-1) and Hif-2 are key mediators of cellular responses to …

Bone marrow, the site of hematopoiesis throughout adulthood, is a physiologically hypoxic
organ. Thus, various biological oxygen sensors and their signaling cascades play a pivotal …

Hypoxia (low O 2) is a fundamental microenvironmental determinant of bone marrow (BM)
pathophysiology. Recent data from molecular and clinical studies indicate that …

OBJECTIVE: Recent evidence suggests that hematopoietic stem cells (HSCs) in the bone
marrow (BM) are located in areas where the environment is hypoxic. Although previous …

Although it has been shown that HIF1 and 2 fulfill essential roles within the hematopoietic
system and in the regulation of HSC fate, little is currently known about the specific …

The hematopoietic stem cell (HSC) pool is maintained under hypoxic conditions within the
bone marrow microenvironment. Cellular responses to hypoxia are largely mediated by the …

The regulation of oxygen (O2) levels is crucial in embryogenesis and adult life, as O2
controls a multitude of key cellular functions. Low oxygen levels (hypoxia) are relevant for …