CD95 is a death receptor whose stimulation by either the physiologic ligand CD95L or the
agonistic antibodies leads to the formation of a multi-molecular complex termed DISC (death …

Binding of either ligand or agonistic antibodies to the death receptor CD95 (APO-1/Fas)
induces the formation of the death-inducing signaling complex (DISC). We now show that …

Abstract CD95 (APO-1/Fas) is a prototype death receptor characterized by the presence of
an 80 amino acid death domain in its cytoplasmic tail. This domain is essential for the …

Activation of the cell surface CD95 receptor triggers a cascade of signaling events, including
assembly of the death‐inducing signaling complex (DISC), that culminate in cellular …

Apoptosis signaling through CD95 (Fas/APO‐1) involves aggregation and clustering of the
receptor followed by its actin‐dependent internalization. Internalization is required for …

The CD95 death receptor plays an important role in several physiological and pathological
apoptotic processes involving in particular the immune system. CD95 ligation leads to …

The CD95 Receptor: Apoptosis Revisited: Cell Skip to Main Content Advertisement Cell This
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CD95 (APO-1/Fas) is an apoptosis-inducing receptor belonging to the tumor necrosis factor
receptor superfamily. Multimerization of CD95 leads to instant recruitment of the signaling …

Abstract CD95 (Apo1/Fas) has been originally identified as the target of cell death-inducing
antibodies. The recognition of CD95 as an apoptosis-triggering receptor represents one of …

Summary The CD95 (Fas/APO-1) death-inducing signaling complex (DISC) is essential for
the initiation of CD95-mediated apoptotic and nonapoptotic responses. The CD95 DISC …