Alu elements make up the largest family of human mobile elements, numbering 1.1 million
copies and comprising 11% of the human genome. As a consequence of evolution and …

Alu elements represent one of the most common sources of homology and homeology in the
human genome. Homeologous recombination between Alu elements represents a major …

Recombination between Alu elements results in genomic deletions associated with many
human genetic disorders. Here, we compare the reference human and chimpanzee …

Highlights•New Alu element insertions continue to cause about 0.1% of new human genetic
diseases.•Alu is ancestrally derived from the 7SL RNA and formed a primate-specific SINE …

Background Recombination rates vary widely across the human genome, but little of that
variation is correlated with known DNA sequence features. The genome contains more than …

The nearly one million Alu repeats in human chromosomes are a potential threat to genome
integrity. Alus form dense clusters where they frequently appear as inverted repeats, a …

Alu elements comprise> 10% of the human genome. We have used a computational biology
approach to analyze the human genomic DNA sequence databases to determine the impact …

The goal of the 1000 Genomes Consortium is to characterize human genome structural
variation (SV), including forms of copy number variations such as deletions, duplications …

Transposable elements are one of major sources to cause genomic instability through
various mechanisms including de novo insertion, insertion-mediated genomic deletion, and …

Repetitive elements comprise nearly half of the human genome. Chromosomal
rearrangements involving these elements occur in somatic and germline cells and are …