Circulating smooth muscle progenitor cells in arterial remodeling

JM Daniel, DG Sedding - Journal of molecular and cellular cardiology, 2011 - Elsevier
The proliferation and migration of vascular smooth muscle cells (SMCs) from the media
toward the intimal layer are key components in vascular proliferative diseases. In addition …

Circulating vascular progenitor cells contribute to vascular repair, remodeling, and lesion formation

M Sata - Trends in cardiovascular medicine, 2003 - Elsevier
Exuberant accumulation of smooth muscle cells (SMCs) plays a principal role in the
pathogenesis of vascular diseases. It has been assumed that SMCs derived from the …

Progenitor cell-derived smooth muscle cells in vascular disease

A Orlandi, M Bennett - Biochemical pharmacology, 2010 - Elsevier
Accumulation of vascular smooth muscle cells (VSMCs) in the tunica intima plays a major
role in the pathogenesis of atherosclerosis and restenosis following endovascular …

Smooth muscle progenitor cells in vascular disease

C Liu, KA Nath, ZS Katusic, NM Caplice - Trends in cardiovascular …, 2004 - Elsevier
Vascular smooth muscle cells have long been described as phenotypically diverse, with
some populations possessing the potential for monoclonal expansion within the adult vessel …

Molecular Strategies to Treat Vascular Diseases Circulating Vascular Progenitor Cell as a Potential Target for Prophylactic Treatment of Atherosclerosis

M Sata - Circulation journal, 2003 - jstage.jst.go.jp
Atherosclerosis is responsible for more than half of all deaths in Western countries.
Numerous studies have reported that accumulation of smooth muscle cells (SMCs) plays a …

Origin of neointimal smooth muscle: we've come full circle

MH Hoofnagle, JA Thomas, BR Wamhoff… - … , and vascular biology, 2006 - Am Heart Assoc
The origin of smooth muscle cells (SMCs) in athero-sclerotic lesions has been a hotly
debated topic for more than four decades. Until recently, it was widely accepted that the …

Circulating smooth muscle progenitor cells in atherosclerosis and plaque rupture: current perspective and methods of analysis

JF Bentzon, E Falk - Vascular pharmacology, 2010 - Elsevier
Smooth muscle cells play a critical role in the development of atherosclerosis and its clinical
complications. They were long thought to derive entirely from preexisting smooth muscle …

Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis

M Sata, A Saiura, A Kunisato, A Tojo, S Okada… - Nature medicine, 2002 - nature.com
Excessive accumulation of smooth-muscle cells (SMCs) has a key role in the pathogenesis
of vascular diseases. It has been assumed that SMCs derived from the outer medial layer …

Smooth muscle progenitor cells: friend or foe in vascular disease?

O Oostrom, JO Fledderus, D de Kleijn… - Current stem cell …, 2009 - ingentaconnect.com
The origin of vascular smooth muscle cells that accumulate in the neointima in vascular
diseases such as transplant arteriosclerosis, atherosclerosis and restenosis remains subject …

Regulation of smooth muscle cells in development and vascular disease: current therapeutic strategies

X Cai - Expert review of cardiovascular therapy, 2006 - Taylor & Francis
Vascular smooth muscle cells (SMCs) exhibit extensive phenotypic diversity and rapid
growth during embryonic development, but maintain a quiescent, differentiated state in adult …