Neonatal hypoxia-ischemia in the preterm human leads to selective injury to the subcortical
developing white matter, which results in periventricular leukomalacia (PVL), a condition …

In the premature infant, hypoxic-ischemic damage to the cerebral white matter
[periventricular leukomalacia (PVL)] is a common and leading cause of brain injury that often …

Brain injury in the premature infant is a problem of enormous importance. Periventricular
leukomalacia (PVL) is the major neuropathologic form of this brain injury and underlies most …

Hypoxic-ischemic injury to the periventricular cerebral white matter [periventricular
leukomalacia (PVL)] results in cerebral palsy and is the leading cause of brain injury in …

Hypoxia-ischemia (HI) is a leading cause of white matter damage, a major contributor to
cerebral palsy in premature infants. Preferential white matter damage is believed to result …

Periventricular leukomalacia in the premature infant is a lesion of cerebral white matter with
its greatest period of risk when white matter is immature, that is, when oligodendrocyte …

Studies of ischemic brain injury in neonatal rodents have focused upon the pathophysiology
of neuronal damage. Much less consideration has been given to white matter injury, even …

Selective patterns of cerebral injury are observed after a variety of insults at different ages
during development. Distinct populations of cells demonstrate selective vulnerability during …

Cerebral hypoxia/ischemia of the newborn has a frequency of 4/1,000 births and remains a
major cause of cerebral palsy, epilepsy, and mental retardation. Despite progress in …

Ischemia is implicated in periventricular white matter injury (PWMI), a lesion associated with
cerebral palsy. PWMI features selective damage to early cells of the oligodendrocyte …