G-protein coupled receptors interact to provide additional regulatory mechanisms for
neurotransmitter signaling. Adenosine A2A receptors are expressed at a high density in …

Dopamine D2 receptors (Rs) and adenosine A2ARs are coexpressed on striatopallidal
neurons, where they mediate opposing actions. In agreement with the idea that D2Rs …

Adenosine is known to modulate dopamine responses in several brain areas. Here, we
show that tonic activation of adenosine receptors is able to impede desensitization of D1 …

Adenosine and dopamine (DA) strongly modulate the neuronal activity in the striatum by pre-
and postsynaptic mechanisms. As several behavioral and molecular studies indicate a …

Dopamine release is regulated by presynaptic dopamine receptors and interactions
between adenosine and dopamine receptors have been well documented. In the present …

The A2AR is largely coexpressed with D2Rs and enkephalin mRNA in the striatum where it
modulates dopaminergic activity. Activation of the A2AR antagonizes D2R-mediated …

It has been shown that striatal adenosine A2A receptors can antagonistically interact with
dopamine D2 receptors at the membrane level leading to a decrease in the affinity and …

In membrane preparations from rat striatum, where adenosine A2A and dopamine D2
receptors are coexpressed, stimulation of adenosine A2A receptors was found to decrease …

To investigate if adenosine A2A receptor stimulation in vivo modulates dopamine D3
receptor binding, we analyzed the effects of 2-[p-(carboxyethyl)-phenylethylamino]-5′-N …

Publisher Summary Repeated administration of amphetamine, cocaine, or morphine has
been reported to result in sensitization to both reinforcing and locomotor stimulant effects on …