Rethinking neuroprotection in severe traumatic brain injury: toward bedside neuroprotection

T Zoerle, M Carbonara, ER Zanier, F Ortolano… - Frontiers in …, 2017 - frontiersin.org
Neuroprotection after traumatic brain injury (TBI) is an important goal pursued strenuously in
the last 30 years. The acute cerebral injury triggers a cascade of biochemical events that …

Neuroprotection for traumatic brain injury: translational challenges and emerging therapeutic strategies

DJ Loane, AI Faden - Trends in pharmacological sciences, 2010 - cell.com
Traumatic brain injury (TBI) causes secondary biochemical changes that contribute to
subsequent tissue damage and associated neuronal cell death. Neuroprotective treatments …

Neuroprotective strategies for traumatic brain injury: improving clinical translation

SV Kabadi, AI Faden - International journal of molecular sciences, 2014 - mdpi.com
Traumatic brain injury (TBI) induces secondary biochemical changes that contribute to
delayed neuroinflammation, neuronal cell death, and neurological dysfunction. Attenuating …

Neuroprotection for traumatic brain injury

DJ Loane, BA Stoica, AI Faden - Handbook of clinical neurology, 2015 - Elsevier
Traumatic brain injury (TBI) is a major cause of mortality and morbidity worldwide. Despite
extensive preclinical research supporting the effectiveness of neuroprotective therapies for …

Targets of neuroprotection and review of pharmacological interventions in traumatic brain injury

MI Hiskens - Journal of Pharmacology and Experimental …, 2022 - ASPET
Traumatic brain injury (TBI) is a major contributor to disability and death worldwide, and
manifests in cognitive, behavioral, and motor impairment. Although there have been …

Neuroprotection in traumatic brain injury: a complex struggle against the biology of nature

JW Schouten - Current opinion in critical care, 2007 - journals.lww.com
Traumatic brain injury is a complex disease, and development of clinically effective
neuroprotective agents is a difficult task. Experimental traumatic brain injury has provided …

Neuropharmacology in traumatic brain injury: from preclinical to clinical neuroprotection?

D Lerouet, C Marchand‐Leroux… - Fundamental & clinical …, 2021 - Wiley Online Library
Traumatic brain injury (TBI) constitutes a major health problem worldwide and is a leading
cause of death and disability in individuals, contributing to devastating socioeconomic …

Neuroprotection in acute brain injury: an up-to-date review

N Stocchetti, FS Taccone, G Citerio, PE Pepe… - Critical care, 2015 - Springer
Neuroprotective strategies that limit secondary tissue loss and/or improve functional
outcomes have been identified in multiple animal models of ischemic, hemorrhagic …

Neuroprotection trials in traumatic brain injury

S Chakraborty, B Skolnick, RK Narayan - Current neurology and …, 2016 - Springer
Traumatic brain injury (TBI) is a significant cause of mortality and morbidity worldwide.
Current treatment of acute TBI includes surgical intervention when needed, followed by …

Exploring new routes for neuroprotective drug development in traumatic brain injury

T Janowitz, DK Menon - Science translational medicine, 2010 - science.org
Worldwide, traumatic brain injury (TBI) is a major cause of mortality and morbidity with a
substantial predicted increase in incidence. Despite an obvious need, there are no …