Background: Colorectal cancer (CRC) is one of the more intensively studied human
malignancies. For many years, the general view has been that the vast majority of CRCs in …

Background/Aim: Conventional (tubular or villous) adenomas, and the more recently
described serrated adenomas, are non-invasive neoplasias that precede colon carcinomas …

Identification of the adenoma-carcinoma sequence with its corresponding molecular genetic
alterations has significantly increased our understanding of the pathogenesis of colorectal …

Aims A recent review of archived sections from early experiments in rats showed neoplasias
exhibiting serrated configurations. The aim was to assess the frequency of serrated …

PURPOSE: In view of the changing concept of colorectal carcinogenesis during the last 20
years, a historical review of colorectal carcinogenesis is presented. METHODS: The …

Carcinogenesis has been shown to be a multistep process. However, the morphological
basis of the multistep process in colonic carcinogenesis has not been adequately …

Until recently, two major forms of colorectal epithelial polyp were recognized: the adenoma
and the hyperplastic polyp. Adenomas were perceived to represent the precursor to …

This review gives a comprehensive overview of cancer development and links it to the
current understanding of tumorigenesis and malignant progression in colorectal cancer. The …

Hyperplastic polyps of the colorectum are known to show dysplastic changes and may be
mixed hyperplastic adenomatous polyps. It is proposed that these polyps are serrated …

Until recently, two major types of colorectal epithelial polyps were distinguished: the
adenoma and the hyperplastic polyp. While adenomas—because of their cytological atypia …