Cyclic hypoxia and alterations in oncogenic signaling contribute to switch cancer cell
metabolism from oxidative phosphorylation to aerobic glycolysis. A major consequence of …

Tumor cell survival relies upon adaptation to the acidic conditions of the tumor
microenvironment. To investigate potential acidosis survival mechanisms, we examined the …

The microenvironment of solid tumors tends to be more acidic (6.5–7.0) than surrounding
normal (7.2–7.4) tissue. Chaotic vasculature, oxygen limitation and major metabolic …

An acidic tumor microenvironment exists widely in solid tumors. However, the detailed
mechanism of cell survival under acidic stress remains unclear. The aim of this study is to …

Proton pump inhibitors (PPI) target tumour acidic pH and have an antineoplastic effect in
melanoma. The PPI esomeprazole (ESOM) kills melanoma cells through a caspase …

Macroautophagy (called autophagy hereafter) is a catabolic process activated by various
types of stress, most notably by nutrient deprivation. The autophagic degradation of …

Several environmental-associated stress conditions, including hypoxia, starvation, oxidative
stress, fast growth and cell death suppression, modulate both cellular metabolism and …

Enhanced autophagy has been observed in hypoxic regions of solid tumors. Here we
address the hypothesis that autophagy is required for survival of hypoxic cells. We evaluated …

Autophagy plays a major role in the adaptive metabolic response of cancer cells during
adverse conditions such as nutrient deprivation. However, specific data that assess …

Sustained autophagy contributes to the metabolic adaptation of cancer cells to hypoxic and
acidic microenvironments. Since cells in such environments are resistant to conventional …