When a heart responds to increased workload it does so by hypertrophy. This is
characterized by an increase in cell size in the absence of cell division, and is accompanied …

Although major pathogenesis mechanisms of heart failure (HF) are well established, the
significance of early (mal) adaptive structural changes of cardiomyocytes preceding …

Structural remodeling of the ventricular wall is a key determinant of clinical outcome in heart
disease. Such remodeling involves the production and destruction of extracellular matrix …

Cardiac diseases, characterized by cardiomyocyte loss, lead to dramatic impairment of
cardiac function and ultimately to congestive heart failure. Despite significant advances …

The heart originates from bilateral primordia that eventually fuse in the embryonic midline
leading to a linear tube. Soon after, the heart bends to the right and atrial and ventricular …

The multiple mechanisms that bring about the decompensation of the hypertrophic
remodeled myocardium are synergistic and not fully understood. Our current hypothesis is …

As the heart matures during embryogenesis from its foetal stages, several structural and
functional modifications take place to form the adult heart. This process of maturation is in …

Modern biology has not transformed the landscape of cardiac insufficiency, CI, but to some
degree in this rather complex domain, it has permitted us to actually distinguish between …

Heart failure represents an enormous clinical challenge in need of effective therapeutic
approaches. The possibility of gene therapy for heart failure merits consideration at this time …

Cardiomyocytes continuously generate the contractile force to circulate blood through the
body. Imbalances in contractile performance or energy supply cause adaptive responses of …