This title reviews current knowledge of the mechanisms contributing to heart failure. Editor
Richard Walsh and an internationally renowned team of contributors discuss key advances …

Epigenetic mechanisms and cell crosstalk have been shown to play important roles in the
initiation and progression of cardiac fibrosis. This review article aims to provide a thorough …

Heart failure (HF) is the inability of the heart to cope with the metabolic demands of the
periphery. It is the common end-stage of many frequent cardiac diseases and is …

Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease and the
leading cause of sudden cardiac death in young people. Mutations in genes that encode …

Many primary or secondary diseases of the myocardium are accompanied with complex
remodelling of the cardiac tissue that results in increased heart mass, often identified as …

Heart failure (HF) develops from a diverse range of genetic and environmental factors that
compromise cardiac function, ultimately resulting in insufficient blood flow to the body. HF is …

End stage heart failure due to ischemic (ICM) or dilated (DCM) cardiomyopathy is
characterized by a dilated, relatively thin-walled ventricle. The hypothesis has been …

Introduction/background: Heart failure is a major cause of cardiovascular morbidity and
mortality. This review covers current heart failure treatment guidelines, emerging therapies …

The past decade has seen an explosion of research into the pathogenesis of cardiac
hypertrophy and remodeling (1). At the cellular level, remodeling can be regarded, in large …

The heart exhibits remarkable adaptive responses to a wide array of genetic and extrinsic
factors to maintain contractile function. When compensatory responses are not sustainable …