The absorption of oral digoxin preparations has been a topic of much concern during the last
5 yean. The completeness of digoxin absorption is proportional to the area under the serum …

The objective was to directly compare the four different “calculation” methods of assessing P-
gp inhibition potential using experimental data obtained from~ 60 structurally diverse …

OBJECTIVE: To review the use of inhibitory constants (Ki) determined from in vitro
experiments in the prediction of the significance of inhibitory drug—drug interactions (DDIs) …

Objectives We determined in vitro the potency of macrolides as P-glycoprotein inhibitors and
tested in hospitalised patients whether coadministration of P-glycoprotein inhibitors leads to …

The effect of Cremophor-EL (Cr-EL) and polysorbate-80 (PS-80) on the transepithelial
permeability of digoxin (DIG) has been evaluated using the reciprocal permeability …

Background and Aims Intestinal transport by P‐glycoprotein is a recently recognized
determinant of drug disposition. However, direct measurements of transporter‐mediated …

Dabigatran etexilate, an oral, reversible, competitive, and direct thrombin inhibitor, is an in
vitro and in vivo substrate of P-glycoprotein (P-gp). Dabigatran etexilate was proposed as an …

P-glycoprotein (P-gp) is a transmembrane efflux transporter which possesses many
important functions in drug absorption, disposition, metabolism, and toxicity. The ultimate …

Our objective was to examine the influence of ritonavir on P-glycoprotein (P-gp) activity in
humans by characterizing the effect of ritonavir on the pharmacokinetics of the P-gp …

It is now well recognized that membrane efflux transporters, especially P-glycoprotein (P-gp;
ABCB1), play a role in determining the absorption, distribution, metabolism, excretion, and …