Permeability-glycoprotein (Pgp) is a drug transporter responsible for the efflux of xenobiotics
out of cells that influence the pharmacokinetics of numerous drugs. However, the role of this …

This article represents the first evidence that the renal secretion of the commonly used drug,
digoxin, is mediated by P-glycoprotein. In this study, it was demonstrated that digoxin is a …

P-glycoprotein (P-gp), the most extensively studied ATP-binding cassette transporter,
functions as a biological barrier by extruding toxic substances and xenobiotics out of cells. In …

Multidrug resistance mediated by ATP binding cassette (ABC) transporters such as P-
glycoprotein (P-gp) represents a serious problem for the development of effective anticancer …

Caco-2 epithelial layers were used as a model to re-evaluate the mechanism (s) by which
intestinal digoxin absorption is limited by its active secretion back into the lumen. It is widely …

The clinical use of digoxin is complicated by a large number of drug interactions leading to
severe toxicity of the cardiac glycoside. The discovery that digoxin is actively secreted by the …

P-glycoprotein (P-gp) is expressed at the blood-brain barrier (BBB) and restricts the
penetration of its substrates into the central nervous system (CNS). In vitro substrate …

A quantitative structure–activity relationship (QSAR) model has been developed to predict
whether a given compound is a P‐glycoprotein (Pgp) substrate or not. The training set …

Aims Studies revealing conflicting results of the functional significance of MDR1 exon 26
C3435T SNP on the disposition of digoxin in different ethnic groups led us to perform a meta …

The role of P‐glycoprotein (P‐gp) and breast cancer resistance protein (BCRP) in drug–drug
interactions (DDIs) and limiting drug absorption as well as restricting the brain penetration of …