Moderate ethanol preconditioning of rat brain cultures engenders neuroprotection against dementia-inducing neuroinflammatory proteins: possible signaling …

MA Collins, EJ Neafsey, K Wang, NJ Achille… - Molecular …, 2010 - Springer
There is no question that chronic alcohol (ethanol) abuse, a leading worldwide problem,
causes neuronal dysfunction and brain damage. However, various epidemiologic studies in …

Inhibition of amyloid-β-induced neurotoxicity and apoptosis by moderate ethanol preconditioning

A Belmadani, S Kumar, M Schipma, MA Collins… - …, 2004 - journals.lww.com
Consumers of moderate amounts of ethanol have a lower risk of Alzheimer's dementia than
do abstainers. In Alzheimer's disease the brain contains many extracellular plaques …

Neuroprotective preconditioning of rat brain cultures with ethanol: potential transduction by PKC isoforms and focal adhesion kinase upstream of increases in effector …

S Sivaswamy, EJ Neafsey… - European Journal of …, 2010 - Wiley Online Library
Preconditioning rat hippocampal–entorhinocortical (HEC) slice or cerebellar cell cultures
with moderate concentrations of ethanol (20–30 mm) neuroprotects against pro …

Essential involvement of the NMDA receptor in ethanol preconditioning‐dependent neuroprotection from amyloid‐βin vitro

RM Mitchell, EJ Neafsey… - Journal of …, 2009 - Wiley Online Library
In several epidemiological studies, moderate ethanol consumption has been associated
with reduced risks of cognitive decline or Alzheimer's dementia. Of potential relevance is that …

Ethanol preconditioning of rat cerebellar cultures targets NMDA receptors to the synapse and enhances peroxiredoxin 2 expression

RM Mitchell, N Tajuddin, EM Campbell, EJ Neafsey… - Brain research, 2016 - Elsevier
Epidemiological studies indicate that light-moderate alcohol (ethanol) consumers tend to
have reduced risks of cognitive impairment and progression to dementia during aging …

Early-life stress lastingly alters the neuroinflammatory response to amyloid pathology in an Alzheimer's disease mouse model

L Hoeijmakers, SR Ruigrok, A Amelianchik… - Brain, behavior, and …, 2017 - Elsevier
Exposure to stress during the sensitive period of early-life increases the risk to develop
cognitive impairments and psychopathology later in life. In addition, early-life stress (ES) …

Alcohol drinking exacerbates neural and behavioral pathology in the 3xTg-AD mouse model of Alzheimer's disease

JL Hoffman, S Faccidomo, M Kim, SM Taylor… - International review of …, 2019 - Elsevier
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that represents the
most common cause of dementia in the United States. Although the link between alcohol …

Combinatorial preconditioning of rat brain cultures with subprotective ethanol and resveratrol concentrations promotes synergistic neuroprotection

N Khodaie, N Tajuddin, RM Mitchell, EJ Neafsey… - Neurotoxicity …, 2018 - Springer
Preconditioning brain cultures with moderate concentrations of ethanol (EtOH) or trans-
resveratrol (RES), key red wine constituents, can prevent amyloid-β (Aβ) neurotoxicity. Past …

Binge ethanol exposure in advanced age elevates neuroinflammation and early indicators of neurodegeneration and cognitive impairment in female mice

PE Anton, LN Rutt, ML Kaufman, N Busquet… - Brain, Behavior, and …, 2024 - Elsevier
Binge drinking is rising among aged adults (> 65 years of age), however the contribution of
alcohol misuse to neurodegenerative disease development is not well understood. Both …

Sex-specific effects of ethanol consumption in older Fischer 344 rats on microglial dynamics and Aβ (1-42) accumulation

P Marsland, AS Vore, EM DaPrano, JM Paluch… - Alcohol, 2023 - Elsevier
Chronic alcohol consumption, Alzheimer's disease (AD), and vascular dementia are all
associated with cognitive decline later in life, raising questions about whether their …