The mGlu5 Receptor Protomer-Mediated Dopamine D2 Receptor Trans-Inhibition Is Dependent on the Adenosine A2A Receptor Protomer: Implications for …
W Romero-Fernandez, JJ Taura, RAJ Crans… - Molecular …, 2022 - Springer
The adenosine A2A receptor (A2AR), dopamine D2 receptor (D2R) and metabotropic
glutamate receptor type 5 (mGluR5) form A2AR-D2R-mGluR5 heteroreceptor complexes in …
glutamate receptor type 5 (mGluR5) form A2AR-D2R-mGluR5 heteroreceptor complexes in …
Receptor heteromerization in adenosine A2A receptor signaling: Relevance for striatal function and Parkinson's disease
K Fuxe, LF Agnati, K Jacobsen, J Hillion, M Canals… - Neurology, 2003 - AAN Enterprises
Recently evidence has been presented that adenosine A2A and dopamine D2 receptors
form functional heteromeric receptor complexes as demonstrated in human neuroblastoma …
form functional heteromeric receptor complexes as demonstrated in human neuroblastoma …
Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice
A Kachroo, LR Orlando, DK Grandy… - Journal of …, 2005 - Soc Neuroscience
Evidence for heteromeric receptor complexes comprising adenosine A2A and metabotropic
glutamate 5 (mGlu5) receptors in striatum has raised the possibility of synergistic …
glutamate 5 (mGlu5) receptors in striatum has raised the possibility of synergistic …
The selective mGlu5 receptor agonist CHPG inhibits quinpirole-induced turning in 6-hydroxydopamine-lesioned rats and modulates the binding characteristics of …
P Popoli, A Pèzzola, M Torvinen, R Reggio… - …, 2001 - Elsevier
In 6-hydroxydopamine-lesioned rats, the selective mGlu5 receptor agonist (RS)-2-Cholro-5-
Hydroxyphenylglycine (CHPG, 1-6 μg/10 μl intracerebroventricularly) significantly inhibited …
Hydroxyphenylglycine (CHPG, 1-6 μg/10 μl intracerebroventricularly) significantly inhibited …
Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher‐order oligomers in living cells
N Cabello, J Gandía, DCG Bertarelli… - Journal of …, 2009 - Wiley Online Library
G protein‐coupled receptors are known to form homo‐and heteromers at the plasma
membrane, but the stoichiometry of these receptor oligomers are relatively unknown. Here …
membrane, but the stoichiometry of these receptor oligomers are relatively unknown. Here …
Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function
The physiological meaning of the coexpression of adenosine A2A receptors and group I
metabotropic glutamate receptors in γ-aminobutyric acid (GABA) ergic striatal neurons is …
metabotropic glutamate receptors in γ-aminobutyric acid (GABA) ergic striatal neurons is …
A2A/D2 receptor heteromerization in a model of Parkinson's disease. Focus on striatal aminoacidergic signaling
L Ferraro, S Beggiato, MC Tomasini, K Fuxe… - Brain research, 2012 - Elsevier
The present manuscript mainly summarizes the basic concepts and the molecular
mechanisms underlying adenosine A2A-dopamine D2 receptor–receptor interactions in the …
mechanisms underlying adenosine A2A-dopamine D2 receptor–receptor interactions in the …
Adenosine heteroreceptor complexes in the basal ganglia are implicated in Parkinson's disease and its treatment
DO Borroto-Escuela, K Fuxe - Journal of neural transmission, 2019 - Springer
The adenosine homo, iso and heteroreceptor complexes in the basal ganglia play a highly
significant role in modulating the indirect and direct pathways and the striosomal projections …
significant role in modulating the indirect and direct pathways and the striosomal projections …
Co‐localization and functional interaction between adenosine A2A and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum
The anti‐Parkinsonian effect of glutamate metabotropic group 5 (mGluR5) and adenosine
A2A receptor antagonists is believed to result from their ability to postsynaptically control the …
A2A receptor antagonists is believed to result from their ability to postsynaptically control the …
Evidence for the heterotetrameric structure of the adenosine A2A–dopamine D2 receptor complex
V Casadó-Anguera, J Bonaventura… - Biochemical Society …, 2016 - portlandpress.com
Heteromers of G-protein-coupled receptors (GPCRs) have emerged as potential novel
targets for drug development. Accumulating evidence indicates that GPCRs can form …
targets for drug development. Accumulating evidence indicates that GPCRs can form …
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