When applied to peripheral fibres in a neonatal rat tail/spinal cord preparation in vitro,
capsaicin (0.2–50 μM) induced an activation, selective desensitization and reduced …

Capsaicin was tested on peripheral fibres in vitro to determine whether evoked
depolarization or desensitization were likely to explain the antinociception observed after …

We have studied the effects of capsaicin, administered at concentrations found to be
antinociceptive in behavioural tests, on nociceptive responses evoked both in spinal dorsal …

Substance P (SP) is present in unmyelinated primary afferent fibres entering the spinal cord
(Hokfelt et al 1975) and has been suggested to be involved in pain transmission in the …

1 We have tested the hypothesis that capsaicin‐induced activation, desensitization and
impairment of peripheral nociceptor function is mediated by separate mechanisms. This was …

The nociceptive threshold as determined by the reaction time in the hot-plate and tail-flick
tests was measured 3 to 4 months after pretreatment of young rats with capsaicin (50 mg kg …

Twenty-seven rats were treated by 475 mg kg− 1 of subcutaneous capsaicin from 2 to 7 days
of their life. After treatment, only 11 rats had survived. Their cutaneous heat, pressure …

The responsiveness to noxious thermal, mechanical, and chemical stimuli was examined in
adult rats that had been treated neonatally with capsaicin. A range of capsaicin doses was …

Acute capsaicin treatment in adult rats has been shown to increase firing rates in peripheral
sensory nerves involved in the transmission of nociceptive input due to chemical irritants or …

We have studied the effect of NE 19550 (olvanil, N-(4-hydroxy-3-methoxyphenyl) methyl-9Z-
octadecenamide), a capsaicin analogue with approximately equipotent antinociceptive …