Metabolic profiling (metabolomics/metabonomics) is the measurement in biological systems
of the complement of low-molecular-weight metabolites and their intermediates that reflects …

Introduction: There are significant rates of attrition in drug development. A number of
compounds fail to progress past preclinical development due to limited tools that accurately …

Background: Metabolic activation leading to formation of chemically reactive drug
metabolites is a long-standing issue for drug development inasmuch as some, but not all …

Adverse drug reactions (ADRs) are a significant human health problem. Any organ system
can be affected, including the liver, skin and kidney. Drug-induced liver injury is the most …

Introduction: Drug metabolism is one of the most important processes involving a drug after
administration. Undesirable pharmacokinetic properties may lead to drug discontinuation. In …

Background: While establishing efficacy in translational models and humans through
clinically-relevant endpoints for disease is of great interest, assessing the potential toxicity of …

Drug metabolism studies, together with pathologic and histologic evaluation, provide critical
data sets to help understand mechanisms underlying drug-related hepatotoxicity. A common …

The issue of chemically reactive drug metabolites is one of growing concern in the
pharmaceutical industry inasmuch as some, but not all, reactive intermediates are believed …

The science of drug metabolism and pharmacokinetics (DMPK) has developed significantly
over the past 20 years, and its functional role in today's pharmaceutical industry has matured …

Metabolism studies play a pivotal role in drug discovery and development. Characterization
of metabolic “hotspots” as well as reactive and pharmacologically active metabolites is …